Abstract
One-pot reductive mono-N-alkylation of aniline and nitroarene derivatives using various aldehydes by Pd/C catalyst in aqueous 2-propanol solvent with ammonium formate as in situ hydrogen donor is illustrated. The reaction proceeded smoothly and selectively with excellent yield at room temperature. Our protocol presents a facile, economical, and environmentally benign alternative for reductive amination.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry*
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Alkylation
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Amines / chemical synthesis*
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Aniline Compounds / chemical synthesis*
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Aniline Compounds / chemistry*
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Carbon / chemistry
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Catalysis
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Molecular Structure
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Nitrobenzenes / chemistry*
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Oxidation-Reduction
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Palladium / chemistry
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Stereoisomerism
Substances
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Aldehydes
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Amines
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Aniline Compounds
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Nitrobenzenes
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Palladium
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Carbon