Abstract
Antiphospholipid syndrome (APS) is identified as the presence of antiphospholipid antibodies (aPLs) in patients with vascular thrombosis and/or pregnancy morbidity (including fetal death, premature birth and habitual abortion). Neurological manifestations in patients with APS are common, whereas movement disorders are rarely seen. We report an extremely rare case of APS presented with parkinsonism and review the literature to address the clinical profile and possible pathophysiologic mechanism of this disorder.
MeSH terms
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Adult
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Anticoagulants / therapeutic use
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Antiparkinson Agents / therapeutic use
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Antiphospholipid Syndrome / complications*
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Brain / blood supply
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Brain / pathology*
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Brain / physiopathology
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Cerebral Arteries / pathology
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Cerebral Arteries / physiopathology
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Corpus Striatum / diagnostic imaging
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Corpus Striatum / metabolism
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Corpus Striatum / physiopathology
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Dementia, Vascular / etiology
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Dementia, Vascular / pathology
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Dementia, Vascular / physiopathology
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Female
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Humans
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Intracranial Thrombosis / etiology*
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Intracranial Thrombosis / pathology*
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Intracranial Thrombosis / physiopathology
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Levodopa / therapeutic use
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Neuropsychological Tests
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Parkinsonian Disorders / etiology*
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Parkinsonian Disorders / pathology*
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Parkinsonian Disorders / physiopathology
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Tomography, Emission-Computed, Single-Photon
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Treatment Outcome
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Warfarin / therapeutic use
Substances
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Anticoagulants
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Antiparkinson Agents
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Levodopa
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Warfarin