Tofisopam inhibits the pharmacokinetics of CYP3A4 substrate midazolam

Eur J Clin Pharmacol. 2008 Jan;64(1):93-4. doi: 10.1007/s00228-007-0397-y. Epub 2007 Nov 8.
No abstract available

Publication types

  • Controlled Clinical Trial
  • Letter

MeSH terms

  • Adjuvants, Anesthesia / pharmacokinetics*
  • Antidepressive Agents / pharmacology*
  • Area Under Curve
  • Benzodiazepines / pharmacology*
  • Cytochrome P-450 CYP3A / drug effects*
  • Cytochrome P-450 CYP3A / metabolism
  • Drug Interactions
  • Half-Life
  • Humans
  • Intestinal Mucosa / metabolism
  • Intestines / drug effects
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Midazolam / pharmacokinetics*

Substances

  • Adjuvants, Anesthesia
  • Antidepressive Agents
  • Benzodiazepines
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • Midazolam
  • tofisopam