Psammaplysenes C and D, cytotoxic alkaloids from Psammoclemma sp

J Nat Prod. 2007 Nov;70(11):1827-9. doi: 10.1021/np0703646. Epub 2007 Nov 8.

Abstract

The sponge Psammoclemma sp. was investigated as part of our studies to discover P2X 7 receptor antagonists for the treatment of inflammatory disease. The biological activity of this extract was found to be due to the cytotoxicity of two new bromotyrosine alkaloids, psammaplysenes C (1) and D (2), and not P2X 7-specific activity. Their structures were determined by 1D and 2D NMR spectroscopy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology*
  • Animals
  • Australia
  • Cytotoxins / chemistry
  • Cytotoxins / isolation & purification*
  • Cytotoxins / pharmacology*
  • Drug Screening Assays, Antitumor
  • Humans
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*
  • Purinergic P2 Receptor Antagonists*
  • Receptors, Purinergic P2X7
  • Tyrosine / analogs & derivatives*
  • Tyrosine / chemistry
  • Tyrosine / isolation & purification
  • Tyrosine / pharmacology

Substances

  • Alkaloids
  • Cytotoxins
  • P2RX7 protein, human
  • Purinergic P2 Receptor Antagonists
  • Receptors, Purinergic P2X7
  • psammaplysene C
  • psammaplysene D
  • Tyrosine