Abstract
During our screening for bioactive natural compounds from microorganisms, a novel alkaloid has been isolated from a terrestrial Streptomyces sp. isolate NR12, and named as benhamycin (1). This was along with the known metabolites, uracil, thymine, p-hydroxybenzoic acid, 2'-deoxyuridin, tryptophol, indolyl-3-carboxylic acid, and indolyl-3-carbaldehyde. Chemical structure of the novel compound was determined by detailed analysis of its spectroscopic data (extensive NMR experiments, 1 & 2D, MS spectroscopy, and MS high resolution). Structurally, Benhamycin (1) is a pentacyclic aromatic compound bearing an acridine moiety lactamized with benzene. Biological studies showed that the strain extract was moderately active against Gram-positive, Gram-negative bacteria and fungi.
MeSH terms
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Acridines / chemistry
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Acridines / isolation & purification*
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Acridines / pharmacology
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Aspergillus niger / drug effects
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Bacillus subtilis / drug effects
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Escherichia coli / drug effects
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Microbial Sensitivity Tests
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Nuclear Magnetic Resonance, Biomolecular
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Streptomyces / chemistry*
Substances
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Acridines
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Alkaloids
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Anti-Bacterial Agents
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Antifungal Agents