Regulation of NK cell activity by 2B4, NTB-A and CRACC

Front Biosci. 2008 Jan 1:13:956-65. doi: 10.2741/2735.

Abstract

2B4, NTB-A and CRACC are members of the recently defined family of SLAM-related receptors. Here we review the role of these receptors for the regulation of Natural Killer cell function and describe the current knowledge about the signal transduction of these receptors. Finally, we critically analyze some controversial data about the function of 2B4 in mouse and man.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / metabolism*
  • Autoimmune Diseases / metabolism
  • Humans
  • Immune System
  • Killer Cells, Natural / metabolism*
  • Lymphocyte Activation
  • Membrane Glycoproteins / metabolism*
  • Mice
  • Models, Biological
  • Receptors, Cell Surface / metabolism*
  • Receptors, Immunologic / metabolism*
  • Signal Transduction
  • Signaling Lymphocytic Activation Molecule Family
  • Signaling Lymphocytic Activation Molecule Family Member 1
  • Th1 Cells / metabolism
  • Th2 Cells / metabolism

Substances

  • Antigens, CD
  • CD244 protein, human
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Receptors, Immunologic
  • SLAMF6 protein, human
  • SLAMF7 protein, human
  • Signaling Lymphocytic Activation Molecule Family
  • Slamf6 protein, mouse
  • Signaling Lymphocytic Activation Molecule Family Member 1