Abstract
The molecular mechanisms required for sensing high osmolarity in the extracellular environment are not well defined in eukaryotes. A recent study showed that yeast Msb2 and Hkr1, which are related to mammalian mucins, are excellent candidates for sensing osmostress and for activating the HOG stress-activated protein kinase pathway involved in osmostress adaptation. Transmembrane mucins activate several signaling cascades in mammals and could therefore be important for sensing osmotic imbalances in higher eukaryotes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Eukaryotic Cells / metabolism*
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Eukaryotic Cells / physiology
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GTPase-Activating Proteins / metabolism
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Intracellular Signaling Peptides and Proteins
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Membrane Proteins / metabolism
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Mitogen-Activated Protein Kinases / metabolism*
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Mucins / metabolism*
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Osmolar Concentration*
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Phosphorylation
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae / physiology
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Saccharomyces cerevisiae Proteins / metabolism*
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Signal Transduction
Substances
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GTPase-Activating Proteins
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HKR1 protein, S cerevisiae
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Intracellular Signaling Peptides and Proteins
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MSB2 protein, S cerevisiae
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Membrane Proteins
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Mucins
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Saccharomyces cerevisiae Proteins
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HOG1 protein, S cerevisiae
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Mitogen-Activated Protein Kinases