In vitro effects of Plasmodium falciparum dihydrofolate reductase inhibitors on normal and cancer cell proliferation

ChemMedChem. 2008 Mar;3(3):421-4. doi: 10.1002/cmdc.200700257.

Authors

Tiziana Rossi¹, Andrea Coppi, Elisa Bruni, Miriam Sgobba, Gianluca Degliesposti, Giulio Rastelli

Affiliation

¹ Dipartimento di Scienze Biomediche, Università di Modena e Reggio Emilia, via Campi 287, 41100 Modena, Italy.

PMID: 17973282
DOI: 10.1002/cmdc.200700257

No abstract available

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use*
Apoptosis / drug effects*
Breast Neoplasms / drug therapy*
Breast Neoplasms / enzymology
Breast Neoplasms / pathology
Cell Line, Tumor
Cell Proliferation / drug effects*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Enzyme Inhibitors / therapeutic use*
Folic Acid Antagonists / chemistry
Folic Acid Antagonists / pharmacology
Folic Acid Antagonists / therapeutic use*
Humans
Plasmodium falciparum / drug effects*
Plasmodium falciparum / enzymology

Substances

Antineoplastic Agents
Enzyme Inhibitors
Folic Acid Antagonists