Asymmetric synthesis of (7aS)-7a-methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and useful derivatives thereof

Samuël Demin; Dirk Van Haver; Pierre J De Clercq

doi:10.3390/11090707

Asymmetric synthesis of (7aS)-7a-methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and useful derivatives thereof

Molecules. 2006 Sep 18;11(9):707-13. doi: 10.3390/11090707.

Authors

Samuël Demin¹, Dirk Van Haver, Pierre J De Clercq

Affiliation

¹ Ghent University, Department of Organic Chemistry, Laboratory for Organic Synthesis, Krijgslaan 281 (S4), B-9000 Gent, Belgium.

Abstract

The enantioselective synthesis of the title compound, using Meyers' bicyclic lactam methodology, is described. This compound and a few of its derivatives are useful intermediates in natural product synthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bridged Bicyclo Compounds / chemical synthesis
Bridged Bicyclo Compounds / chemistry
Indenes / chemical synthesis*
Indenes / chemistry
Ketones / chemical synthesis*
Ketones / chemistry
Lactams / chemistry
Stereoisomerism

Substances

Bridged Bicyclo Compounds
Indenes
Ketones
Lactams