[Hydroxy(tosyloxy)iodo]benzene mediated alpha-azidation of ketones

Om Prakash; Kamaljeet Pannu; Richa Prakash; Anita Batra

doi:10.3390/11070523

[Hydroxy(tosyloxy)iodo]benzene mediated alpha-azidation of ketones

Molecules. 2006 Jul 14;11(7):523-7. doi: 10.3390/11070523.

Authors

Om Prakash¹, Kamaljeet Pannu, Richa Prakash, Anita Batra

Affiliation

¹ Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India. dromprakash50@rediffmail.com

Abstract

Reaction of various ketones with [hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment of the alpha-tosyloxy ketones thus generated in situ with NaN3 offers a one-pot procedure for the synthesis of alpha-azido ketones. The HTIB used in this conversion may also be generated in situ by using iodosobenzene in combination with p-toluene-sulphonic acid.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Azides / chemistry*
Benzenesulfonates / chemistry
Iodobenzenes / chemistry*
Ketones / chemistry*

Substances

Azides
Benzenesulfonates
Iodobenzenes
Ketones
4-toluenesulfonic acid
iodosobenzene