Repeated exposures to hyperbaric air suppress neurite outgrowth in PC12 cells

Tetsuro Isada; Munetaka Hirose; Eri Murata; Yoko Okayama; Mayumi Takatori; Mayumi Tani; Keita Fukazawa; Masashi Hirata; Satoshi Taniguchi; Kenji Shigemi; Yoshifumi Tanaka

doi:10.2170/physiolsci.SC009707

Repeated exposures to hyperbaric air suppress neurite outgrowth in PC12 cells

J Physiol Sci. 2007 Oct;57(5):321-5. doi: 10.2170/physiolsci.SC009707. Epub 2007 Nov 1.

Authors

Tetsuro Isada¹, Munetaka Hirose, Eri Murata, Yoko Okayama, Mayumi Takatori, Mayumi Tani, Keita Fukazawa, Masashi Hirata, Satoshi Taniguchi, Kenji Shigemi, Yoshifumi Tanaka

Affiliation

¹ Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences, Fukui University, Eiheijicho, Yoshidagun, Fukui, 910-1193, Japan.

PMID: 17971265
DOI: 10.2170/physiolsci.SC009707

Abstract

Hyperbaric exposure induces lesions of the CNS in scuba divers. Repeated exposures to hyperbaric air at 0.5 MPa for 30 min with short intervals suppressed NGF-stimulated neurite outgrowth, concomitant with a decrease in the protein expression of ERK in PC12 cells. Hyperbaric exposure most likely causes direct lesions of neural cells.

MeSH terms

Air Pressure*
Animals
Cell Differentiation / physiology*
Extracellular Signal-Regulated MAP Kinases / analysis
Extracellular Signal-Regulated MAP Kinases / metabolism
Nerve Growth Factor / pharmacology
Neurites / drug effects
Neurites / physiology*
PC12 Cells
Phosphorylation
Rats
Receptor, trkA / metabolism

Substances

Nerve Growth Factor
Receptor, trkA
Extracellular Signal-Regulated MAP Kinases