In 1942, Stafne was the first to report radiographic findings of "static bone cavities" situated near the angle of the mandible. The typical radiographic appearance of Stafne's mandibular defect is a radiolucency below the inferior alveolar canal, between the mandibular premolars and the angle of the mandible. Stafne's mandibular defect ranges from 10 mm to 30 mm in diameter. The size has been shown to be remarkably constant in diagnosed lesions followed over time. In the majority of cases, the lesion is symptomless. Routine surgical exploration is not indicated. It is suggested that the lesion is a radiographic rather than a pathological entity; therefore, consideration was given to making use of these anatomical retentive areas in a prosthetic manner. In this article, a literature review of Stafne's mandibular defect is presented and attempts to improve the retention and stability of the lower complete dentures by using this anatomical entity are described.