Thrombin-like activity in snake venoms from Peruvian Bothrops and Lachesis genera

P Orejuela; A Zavaleta; M Salas; N Marsh

doi:10.1016/0041-0101(91)90212-a

Thrombin-like activity in snake venoms from Peruvian Bothrops and Lachesis genera

Toxicon. 1991;29(9):1151-4. doi: 10.1016/0041-0101(91)90212-a.

Authors

P Orejuela¹, A Zavaleta, M Salas, N Marsh

Affiliation

¹ Departamento de Ciencias Fisiológicas, Universidad Peruana Cayetano Heredia, Lima, Perú.

PMID: 1796478
DOI: 10.1016/0041-0101(91)90212-a

Abstract

Venoms from Lachesis muta muta, Bothrops pictus, B. barnetti, B. atrox and B. hyoprorus coagulate in vitro canine fibrinogen, and both bovine fibrinogen and bovine plasma. B. barnetti and L. muta muta venoms have greater activity on canine fibrinogen and B. atrox and B. hyoprorus venoms, a greater activity on bovine fibrinogen. Gel filtration showed one peak of coagulant activity in all venoms except B. atrox venom which possessed two peaks. The apparent mol. wt of these enzymes ranged from 45,000 to 69,000.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Coagulation / drug effects*
Cattle
Chemical Fractionation
Chromatography, Gel
Crotalid Venoms / chemistry
Crotalid Venoms / toxicity*
Dogs
Fibrinogen / metabolism*
Molecular Weight
Thrombin / metabolism

Substances

Crotalid Venoms
Fibrinogen
Thrombin