Synthesis and antidepressant evaluation of three para-benzoquinone mono-oximes and their oxy derivatives

Damião Pergentino de Sousa; Renata Rabelo Schefer; Ursula Brocksom; Timothy John Brocksom

doi:10.3390/11020148

Synthesis and antidepressant evaluation of three para-benzoquinone mono-oximes and their oxy derivatives

Molecules. 2006 Mar 10;11(2):148-55. doi: 10.3390/11020148.

Authors

Damião Pergentino de Sousa¹, Renata Rabelo Schefer, Ursula Brocksom, Timothy John Brocksom

Affiliation

¹ Laboratório de Química Bio-Orgânica, Departamento de Química, Universidade Federal de São Carlos, Caixa Postal 676, 13565-905 São Carlos, SP, Brazil. damiao50@yahoo.com.br

Abstract

A series of three para-benzoquinone mono-oximes and four oxy-derivatives were prepared and tested for their antidepressant properties. The (4E) oxime of 2-isopropyl-5-methyl-para-benzoquinone (4) and the corresponding 2-diethylamino-ethyl derivative (10) present antidepressant activities and were slightly more potent than the reference standard.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antidepressive Agents / chemical synthesis
Antidepressive Agents / chemistry
Antidepressive Agents / pharmacology*
Behavior, Animal / drug effects*
Benzoquinones / chemistry*
Male
Mice
Oximes / chemical synthesis*
Oximes / chemistry
Oximes / pharmacology
Structure-Activity Relationship
Swimming
Water

Substances

Antidepressive Agents
Benzoquinones
Oximes
Water
quinone