Synthesis of ring-contracted erythromycin A derivatives via microwave-assisted intramolecular transesterification

Kai Bao; Weige Zhang; Chuanliang Zhang; Yingwei Qu; Liang Tian; Lan Wu; Xiang Zhao; Maosheng Cheng

doi:10.3390/12092123

Synthesis of ring-contracted erythromycin A derivatives via microwave-assisted intramolecular transesterification

Molecules. 2007 Aug 30;12(9):2123-9. doi: 10.3390/12092123.

Authors

Kai Bao¹, Weige Zhang, Chuanliang Zhang, Yingwei Qu, Liang Tian, Lan Wu, Xiang Zhao, Maosheng Cheng

Affiliation

¹ School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.

Abstract

The synthesis of ring-contracted derivatives of erythromycin A via intramolecular transesterification under microwave irradiation of 8,9-anhydroerythromycin A 6,9-hemiketal and its derivatives is described. It was found that microwave irradiation could significantly improve the yields and shorten the reaction times under either solvent-containing (method A) or solvent-free (method B) conditions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Erythromycin / analogs & derivatives*
Erythromycin / chemical synthesis*
Erythromycin / chemistry
Esterification
Microwaves*

Substances

Erythromycin