Tourette's syndrome is not associated with interleukin-10 receptor 1 variants on chromosome 11q23.3

Jochen Kindler; Alexandra Schosser; Mara Stamenkovic; Monika Schloegelhofer; Friedrich Leisch; Kurt Hornik; Harald Aschauer; Christoph Gasche

doi:10.1016/j.psychres.2007.07.021

Tourette's syndrome is not associated with interleukin-10 receptor 1 variants on chromosome 11q23.3

Psychiatry Res. 2008 Jan 15;157(1-3):235-9. doi: 10.1016/j.psychres.2007.07.021. Epub 2007 Oct 24.

Authors

Jochen Kindler¹, Alexandra Schosser, Mara Stamenkovic, Monika Schloegelhofer, Friedrich Leisch, Kurt Hornik, Harald Aschauer, Christoph Gasche

Affiliation

¹ Department of Biological Psychiatry, University Hospital of Psychiatry and Psychotherapy, Medical University of Vienna, Austria. jochen.kindler@gef.be.ch

PMID: 17961716
DOI: 10.1016/j.psychres.2007.07.021

Abstract

Interleukin-10 receptor 1 (IL-10R1) single nucleotide polymorphisms, located on chromosome 11q23 - a strong candidate for linkage with Tourette's syndrome (TS) - have been investigated for association with TS. DNA of 77 patients with a DSM-IV (Diagnostic and Statistical Manual IV) diagnosis of TS and 250 healthy controls was genotyped. IL-10R1 was not associated with TS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alleles
Autoantibodies / immunology
Chromosomes, Human, Pair 11 / genetics*
Female
Genotype
Humans
Interleukin-10 Receptor alpha Subunit / genetics*
Interleukin-10 Receptor alpha Subunit / immunology
Male
Polymerase Chain Reaction
Tourette Syndrome / genetics*
Tourette Syndrome / immunology

Substances

Autoantibodies
Interleukin-10 Receptor alpha Subunit