New polyhydroxylated furostanol saponins with inhibitory action against NO production from Tupistra chinensis rhizomes

Molecules. 2007 Aug 23;12(8):2029-37. doi: 10.3390/12082029.

Abstract

Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,7alpha,22xi,26-octaol-6-one-26-O-beta-D-glucopyranoside (1) and 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,6beta,7alpha,22xi,26-nonaol-26-O-beta-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 microg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Lipopolysaccharides / pharmacology
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Nitric Oxide / antagonists & inhibitors*
  • Nitric Oxide / biosynthesis
  • Rats
  • Rhizome / chemistry*
  • Saponins / chemistry*
  • Saponins / isolation & purification
  • Saponins / pharmacology*

Substances

  • 5-furost-delta(25(27))-en-1,2,3,4,5,6,7,22zeta,26-nonaol-26-O-glucopyranoside
  • 5-furost-delta(25(27))-en-1,2,3,4,5,7,22zeta,26-octaol-6-one-26-O-glucopyranoside
  • Lipopolysaccharides
  • Saponins
  • Nitric Oxide