Thermoregulation: channels that are cool to the core

Curr Biol. 2007 Oct 23;17(20):R885-7. doi: 10.1016/j.cub.2007.08.016.

Abstract

TRP channels are molecular sensors that endow animals with the ability to sense external temperatures. Recent studies have provided strong evidence that at least one TRP channel, TRPV1, is also essential for the maintenance of internal body temperature.

Publication types

  • Comment
  • Review

MeSH terms

  • Acrylamides / pharmacology
  • Animals
  • Body Temperature Regulation / drug effects
  • Body Temperature Regulation / physiology*
  • Humans
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Pyridines / pharmacology
  • Rats
  • TRPV Cation Channels / antagonists & inhibitors
  • TRPV Cation Channels / deficiency
  • TRPV Cation Channels / physiology*

Substances

  • Acrylamides
  • N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide
  • Pyridines
  • TRPV Cation Channels
  • TRPV1 protein, mouse
  • Trpv1 protein, rat