Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia

Antimicrob Agents Chemother. 2008 Jan;52(1):348-50. doi: 10.1128/AAC.00779-07. Epub 2007 Oct 22.

Abstract

Among 380 Mycoplasma pneumoniae isolates from 3,678 pediatric patients with community-acquired pneumonia, 50 macrolide-resistant strains had an A2063G transition in domain V of the 23S rRNA, whereas 5 had an A2064G transition. These resistant strains increased rapidly from April 2002 to December 2006.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / pharmacology*
  • Child
  • Child, Preschool
  • Community-Acquired Infections / drug therapy*
  • Community-Acquired Infections / microbiology
  • Drug Resistance, Bacterial*
  • Humans
  • Infant
  • Infant, Newborn
  • Macrolides / pharmacology*
  • Microbial Sensitivity Tests
  • Mycoplasma pneumoniae / drug effects*
  • Pneumonia, Mycoplasma / drug therapy*
  • Pneumonia, Mycoplasma / microbiology
  • RNA, Ribosomal, 23S / genetics

Substances

  • Anti-Bacterial Agents
  • Macrolides
  • RNA, Ribosomal, 23S