Effects of acute hippocampal stimulation on EEG dynamics

Conf Proc IEEE Eng Med Biol Soc. 2006:2006:4382-6. doi: 10.1109/IEMBS.2006.260830.

Abstract

Progressive preictal dynamical convergence and postictal divergence of dynamical EEG descriptors among brain regions has been reported in human temporal lobe epilepsy (TLE) and in a rodent model of TLE. There are also reports of anticonvulsant effects of high frequency stimulation of the hippocampus in humans. We postulate that this anticonvulsant effect is due to dynamical resetting by the electrical stimulation. The following study investigated the effects of acute hippocampal electrical stimulation on dynamical transitions in the brain of a spontaneously seizing animal model of TLE to test the hypothesis of divergence in dynamical values by electrical stimulation of the hippocampus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Anticonvulsants / pharmacology
  • Electric Stimulation
  • Electroencephalography / instrumentation*
  • Electroencephalography / methods*
  • Epilepsy, Temporal Lobe / pathology
  • Epilepsy, Temporal Lobe / therapy*
  • Equipment Design
  • Hippocampus / metabolism
  • Hippocampus / pathology*
  • Humans
  • Male
  • Models, Statistical
  • Rats
  • Seizures
  • Temporal Lobe / pathology*
  • Time Factors

Substances

  • Anticonvulsants