Hybrid automata as a unifying framework for modeling excitable cells

Conf Proc IEEE Eng Med Biol Soc. 2006:2006:4151-4. doi: 10.1109/IEMBS.2006.259294.

Abstract

We propose hybrid automata (HA) as a unifying framework for computational models of excitable cells. HA, which combine discrete transition graphs with continuous dynamics, can be naturally used to obtain a piecewise, possibly linear, approximation of a nonlinear excitable-cell model. We first show how HA can be used to efficiently capture the action-potential morphology--as well as reproduce typical excitable-cell characteristics such as refractoriness and restitution--of the dynamic Luo-Rudy model of a guinea-pig ventricular myocyte. We then recast two well-known computational models, Biktashev's and Fenton-Karma, as HA without any loss of expressiveness. Given that HA possess an intuitive graphical representation and are supported by a rich mathematical theory and numerous analysis tools, we argue that they are well positioned as a computational model for biological processes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms
  • Animals
  • Artificial Intelligence
  • Automation
  • Guinea Pigs
  • Heart Ventricles
  • Models, Biological
  • Models, Cardiovascular
  • Myocytes, Cardiac / cytology*
  • Myocytes, Cardiac / physiology*
  • Nonlinear Dynamics
  • Oscillometry