Bio-behavioral control, glucose variability, and hypoglycemia-associated autonomic failure in type 1 diabetes (T1DM)

Conf Proc IEEE Eng Med Biol Soc. 2006:2006:315-8. doi: 10.1109/IEMBS.2006.260113.

Abstract

In this paper we present a mathematical model and a computer simulation of the relationship between behavioral control of Type 1 diabetes (T1DM), blood glucose (BG) variability, and hypoglycemia-associated autonomic failure (HAAF). A stochastic behavioral self-control process was coupled with a dynamical system simulation of the dampening effect of counterregulation on BG oscillations. The resulting bio-behavioral control system was able to reproduce characteristics of hypoglycemic events in the field, such as temporal clustering of hypoglycemic episodes associated with HAAF, and occurrence of severe hypoglycemia as a result of periods of HAAF augmented by increased BG variability.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Autonomic Nervous System Diseases / blood
  • Autonomic Nervous System Diseases / diagnosis*
  • Autonomic Nervous System Diseases / etiology
  • Autonomic Nervous System Diseases / prevention & control
  • Blood Glucose / analysis*
  • Blood Glucose Self-Monitoring / methods*
  • Computer Simulation
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / diagnosis*
  • Diabetes Mellitus, Type 1 / prevention & control*
  • Female
  • Humans
  • Hypoglycemia / blood
  • Hypoglycemia / diagnosis*
  • Hypoglycemia / etiology
  • Hypoglycemia / prevention & control*
  • Male
  • Models, Biological*
  • Self Care / methods*
  • Treatment Outcome

Substances

  • Blood Glucose