[Women with poor response to ovarian stimulation have increased follicular bone morphogenetic protein-15 levels]

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007 Sep;36(5):439-42. doi: 10.3785/j.issn.1008-9292.2007.05.005.
[Article in Chinese]

Abstract

Objective: To evaluate the levels of bone morphogenetic protein-15 (BMP-15) in human follicular fluid (FF) and its association with response to ovarian stimulation.

Methods: Western blotting was performed to determine the levels of BMP-15 in FF obtained from follicle aspirates in 70 patients undergoing IVF treatment. According to the response to ovarian stimulation the patients were divided into poor responder group and normal responder group.

Result: BMP-15 levels in FF of poor responders were significantly higher than those in normal responders (1.01 +/- 0.34 vs 0.77 +/- 0.24, P<0.01).

Conclusion: Increased levels of BMP-15 in FF may be associated with poor response to ovarian stimulation.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blotting, Western
  • Bone Morphogenetic Protein 15
  • Female
  • Follicle Stimulating Hormone / administration & dosage
  • Follicular Fluid / drug effects
  • Follicular Fluid / metabolism*
  • Gonadotropin-Releasing Hormone / administration & dosage
  • Gonadotropin-Releasing Hormone / analogs & derivatives
  • Growth Differentiation Factor 9
  • Humans
  • Infertility, Female / metabolism*
  • Intercellular Signaling Peptides and Proteins / biosynthesis*
  • Ovary / drug effects
  • Ovary / metabolism*
  • Ovulation Induction

Substances

  • BMP15 protein, human
  • Bone Morphogenetic Protein 15
  • GDF9 protein, human
  • Growth Differentiation Factor 9
  • Intercellular Signaling Peptides and Proteins
  • Gonadotropin-Releasing Hormone
  • LHRH, Ala(6)-Gly(10)-ethylamide-
  • Follicle Stimulating Hormone