Retrovirus silencing by an epigenetic TRIM

Cell. 2007 Oct 5;131(1):13-4. doi: 10.1016/j.cell.2007.09.029.

Abstract

Embryonic cells silence transcription by retroviruses, but how do they recognize virus DNA? In this issue, Wolf and Goff (2007) report that a TRIM28 corepressor complex binds to the retrovirus primer binding site. Epigenetic silencing of retrovirus transcription is accomplished by "writing" a dimethyl mark on lysine 9 of histone H3 that is read by the heterochromatin protein HP1gamma.

Publication types

  • Comment

MeSH terms

  • Animals
  • Binding Sites
  • Chromosomal Proteins, Non-Histone / metabolism
  • Embryonic Stem Cells / physiology*
  • Epigenesis, Genetic*
  • Gene Silencing*
  • Histones / metabolism
  • Humans
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism
  • Regulatory Elements, Transcriptional
  • Repressor Proteins / genetics*
  • Repressor Proteins / metabolism
  • Retroviridae* / genetics
  • Retroviridae* / metabolism
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Transcription, Genetic
  • Tripartite Motif-Containing Protein 28

Substances

  • CBX3 protein, human
  • Chromosomal Proteins, Non-Histone
  • Histones
  • Nuclear Proteins
  • Repressor Proteins
  • Transcription Factors
  • Trim28 protein, mouse
  • Tripartite Motif-Containing Protein 28