Abstract
Embryonic cells silence transcription by retroviruses, but how do they recognize virus DNA? In this issue, Wolf and Goff (2007) report that a TRIM28 corepressor complex binds to the retrovirus primer binding site. Epigenetic silencing of retrovirus transcription is accomplished by "writing" a dimethyl mark on lysine 9 of histone H3 that is read by the heterochromatin protein HP1gamma.
MeSH terms
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Animals
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Binding Sites
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Chromosomal Proteins, Non-Histone / metabolism
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Embryonic Stem Cells / physiology*
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Epigenesis, Genetic*
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Gene Silencing*
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Histones / metabolism
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Humans
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Nuclear Proteins / genetics*
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Nuclear Proteins / metabolism
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Regulatory Elements, Transcriptional
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Repressor Proteins / genetics*
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Repressor Proteins / metabolism
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Retroviridae* / genetics
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Retroviridae* / metabolism
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Transcription Factors / genetics*
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Transcription Factors / metabolism
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Transcription, Genetic
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Tripartite Motif-Containing Protein 28
Substances
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CBX3 protein, human
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Chromosomal Proteins, Non-Histone
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Histones
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Nuclear Proteins
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Repressor Proteins
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Transcription Factors
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Trim28 protein, mouse
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Tripartite Motif-Containing Protein 28