Amphidinolides B6 and B7, cytotoxic macrolides from a symbiotic dinoflagellate Amphidinium species

Keiko Oguchi; Masashi Tsuda; Rie Iwamoto; Yumiko Okamoto; Taeko Endo; Jun'ichi Kobayashi; Tomoko Ozawa; Atsunori Masuda

doi:10.1021/np0703085

Amphidinolides B6 and B7, cytotoxic macrolides from a symbiotic dinoflagellate Amphidinium species

J Nat Prod. 2007 Oct;70(10):1676-9. doi: 10.1021/np0703085. Epub 2007 Oct 9.

Authors

Keiko Oguchi¹, Masashi Tsuda, Rie Iwamoto, Yumiko Okamoto, Taeko Endo, Jun'ichi Kobayashi, Tomoko Ozawa, Atsunori Masuda

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

PMID: 17922551
DOI: 10.1021/np0703085

Abstract

Two 26-membered macrolides, amphidinolides B6 ( 2) and B7 ( 1), have been isolated from a marine symbiotic dinoflagellate Amphidinium sp., and the structures were elucidated on the basis of detailed analyses of 2D NMR data. The relative and absolute configurations for 1 and 2 were assigned by comparison of NMR data and CD data with those of known amphidinolides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Circular Dichroism
Dinoflagellida / chemistry*
Macrolides / chemistry
Macrolides / isolation & purification*
Macrolides / pharmacology*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular

Substances

Macrolides
amphidinolide B6
amphidinolide B7