Impairment of recognition memory in interleukin-6 knock-out mice

Eur J Pharmacol. 2007 Dec 22;577(1-3):219-20. doi: 10.1016/j.ejphar.2007.08.046. Epub 2007 Sep 19.

Abstract

We have used transgenic male mice not expressing interleukin-6 (IL-6) [C57BL/6J(IL-6/-tm Kopf)] in object recognition test to assess the role of endogenous IL-6 in recognition memory. Wild-type controls showed better memory than IL-6 knock-out mice. Results of our experiment suggest that endogenous IL-6 may play an important role in the process of recognition memory in mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Interleukin-6 / genetics*
  • Interleukin-6 / physiology*
  • Male
  • Memory / physiology*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Psychomotor Performance / drug effects
  • Recognition, Psychology / physiology*

Substances

  • Interleukin-6