Clerodane diterpenoids and flavonoids with NGF-potentiating activity from the aerial parts of Baccharis gaudichaudiana

Chem Pharm Bull (Tokyo). 2007 Oct;55(10):1532-4. doi: 10.1248/cpb.55.1532.

Abstract

A new clerodane diterpene, 15-hydroxy-16-acetoxy-ent-clerod-3-en-18-oic acid (1), together with three known clerodane diterpenes (2-4) and three known flavones (5-7), were isolated from the aerial parts of Baccharis gaudichaudiana. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2, 3, and 5 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Baccharis / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Diterpenes, Clerodane / isolation & purification
  • Diterpenes, Clerodane / pharmacology*
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology*
  • Molecular Structure
  • Nerve Growth Factor / pharmacology
  • Neurites / drug effects*
  • PC12 Cells
  • Plant Components, Aerial / chemistry*
  • Rats
  • Spectrum Analysis

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Diterpenes, Clerodane
  • Flavonoids
  • Nerve Growth Factor