Abstract
Three novel cytotoxic substances named prenylterphenyllin (1), 4''-deoxyprenylterphenyllin (2), and 4''-deoxyisoterprenin (3) were isolated from a cultured marine-derived fungus of Aspergillus candidus IF10 together with 4''-deoxyterprenin (4). Their chemical structures were elucidated on the basis of 2D NMR analysis. These compounds 1 approximately 4 showed cytotoxic activity against human epidermoid carcinoma KB cells (KB3-1) with IC(50) of 8.5, 3.0, 2.5, and 4.5 microg/ml, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Aspergillus / chemistry*
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Biphenyl Compounds / isolation & purification
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Biphenyl Compounds / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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KB Cells
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Magnetic Resonance Spectroscopy
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Terphenyl Compounds / isolation & purification
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Terphenyl Compounds / pharmacology*
Substances
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4''-deoxyisoterprenin
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4''-deoxyprenylterphenyllin
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4''-deoxyterprenin
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Antineoplastic Agents
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Biphenyl Compounds
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Terphenyl Compounds
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prenylterphenyllin