Prenylterphenyllin and its dehydroxyl analogs, new cytotoxic substances from a marine-derived Fungus Aspergillus candidus IF10

J Antibiot (Tokyo). 2007 Sep;60(9):586-90. doi: 10.1038/ja.2007.75.

Abstract

Three novel cytotoxic substances named prenylterphenyllin (1), 4''-deoxyprenylterphenyllin (2), and 4''-deoxyisoterprenin (3) were isolated from a cultured marine-derived fungus of Aspergillus candidus IF10 together with 4''-deoxyterprenin (4). Their chemical structures were elucidated on the basis of 2D NMR analysis. These compounds 1 approximately 4 showed cytotoxic activity against human epidermoid carcinoma KB cells (KB3-1) with IC(50) of 8.5, 3.0, 2.5, and 4.5 microg/ml, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Aspergillus / chemistry*
  • Biphenyl Compounds / isolation & purification
  • Biphenyl Compounds / pharmacology*
  • Drug Screening Assays, Antitumor
  • Humans
  • Inhibitory Concentration 50
  • KB Cells
  • Magnetic Resonance Spectroscopy
  • Terphenyl Compounds / isolation & purification
  • Terphenyl Compounds / pharmacology*

Substances

  • 4''-deoxyisoterprenin
  • 4''-deoxyprenylterphenyllin
  • 4''-deoxyterprenin
  • Antineoplastic Agents
  • Biphenyl Compounds
  • Terphenyl Compounds
  • prenylterphenyllin