Pituitary adenoma with tumoral granulomatous reaction

Bernd W Scheithauer; Ana Isabel Silva; John L D Atkinson; Todd B Nippoldt; Timothy J Kaufmann; Kalman Kovacs; Eva Horvath; Ricardo Lloyd

doi:10.1007/s12022-007-0017-5

Pituitary adenoma with tumoral granulomatous reaction

Endocr Pathol. 2007 Summer;18(2):86-90. doi: 10.1007/s12022-007-0017-5.

Authors

Bernd W Scheithauer¹, Ana Isabel Silva, John L D Atkinson, Todd B Nippoldt, Timothy J Kaufmann, Kalman Kovacs, Eva Horvath, Ricardo Lloyd

Affiliation

¹ Department of Pathology and Laboratory Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. scheithauer.bernd@mayo.edu

PMID: 17916998
DOI: 10.1007/s12022-007-0017-5

Abstract

Herein, we report a unique case of an adult male with a corticotrophic pituitary adenoma of silent subtype 1 exhibiting conspicuous idiopathic tumoral noncaseating granulomatous inflammation. The lesion was unassociated with clinical or laboratory evidence of either systemic sarcoidosis or infection. Histochemical and polymerase chain reaction (PCR) studies revealed neither fungi nor tubercle bacilli. We suggest that tumoral production of an as yet uncharacterized antigen may have induced the granulomatous inflammatory reaction.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

ACTH-Secreting Pituitary Adenoma / pathology*
ACTH-Secreting Pituitary Adenoma / surgery
Adenoma / pathology*
Adenoma / surgery
Blood Pressure
Granuloma / pathology*
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Male
Microscopy, Electron
Middle Aged
Pituitary Hormones / blood
Pituitary Neoplasms / pathology*
Pituitary Neoplasms / surgery
Reverse Transcriptase Polymerase Chain Reaction
Testosterone / blood
Thyrotropin / blood
Thyroxine / blood
Vision Disorders / etiology

Substances

Pituitary Hormones
Testosterone
Thyrotropin
Thyroxine