Abstract
A neamine dimer designed to bind to a specific sequence of HIV-1 RNA has been synthesized. Starting from neomycin B (1), a five-step synthesis efficiently provided a key protected neamine monomer 6 (28%). From the latter, coupling reactions with activated diacids gave dimers. After deprotection, a neamine dimer was obtained as the hexachlorohydrate salt 15 with 13% overall yield over nine steps.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoglycosides / chemistry*
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Aminoglycosides / pharmacology
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Anti-HIV Agents / chemical synthesis*
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Dimerization
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Framycetin / chemistry*
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Framycetin / pharmacology
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HIV-1 / genetics*
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Molecular Structure
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Nucleic Acid Conformation
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RNA, Viral / chemistry*
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RNA, Viral / genetics*
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Transcription Initiation Site*
Substances
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Aminoglycosides
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Anti-HIV Agents
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RNA, Viral
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Framycetin
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neamine