Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen

AAPS PharmSciTech. 2007 Sep 21;8(3):E76. doi: 10.1208/pt0803076.

Abstract

The purpose of the present research was to produce a quick/slow biphasic delivery system for ibuprofen. A dual-component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (ibuprofen). The sustained release effect was achieved with a polymer (hydroxypropyl methylcellulose [HPMC] or ethylcellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the ibuprofen contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (approximately 16 or >24 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the HPMC core was suitable for providing a constant and controlled release (zero order) for a long period of time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Delivery Systems*
  • Hypromellose Derivatives
  • Ibuprofen / administration & dosage*
  • Ibuprofen / chemistry
  • Methylcellulose / administration & dosage
  • Methylcellulose / analogs & derivatives
  • Solubility
  • Tablets

Substances

  • Tablets
  • Hypromellose Derivatives
  • Methylcellulose
  • Ibuprofen