Abstract
Contrast-induced nephropathy (CIN) is a common cause of acute kidney injury in hospitalized patients. The mechanisms involved in the pathogenesis of CIN are incompletely understood. Goodman et al. have demonstrated for the first time that heme oxygenase-1, a 32-kilodalton protein with antioxidant, antiapoptotic, anti-inflammatory effects, is induced in the kidney and, importantly, provides a beneficial effect in CIN.
MeSH terms
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Acute Kidney Injury / chemically induced*
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Acute Kidney Injury / metabolism
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Acute Kidney Injury / prevention & control*
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Animals
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Contrast Media / adverse effects*
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Disease Models, Animal
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Heme Oxygenase-1 / metabolism*
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Humans
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Kidney Cortex / metabolism
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Kidney Cortex / pathology
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Kidney Medulla / metabolism
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Kidney Medulla / pathology
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Male
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Rats
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bcl-X Protein / metabolism
Substances
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Bcl2l1 protein, rat
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Contrast Media
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Proto-Oncogene Proteins c-bcl-2
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bcl-X Protein
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Heme Oxygenase-1