Information technology (IT) infrastructures for research collaboratories and virtual research businesses are essential elements of science in medicine. The sustainability of the infrastructure depends on how it becomes a normal element of the scientific process, including its financing as part of a scientist's workbench that can be easily configured to their needs. The results should also be distributed through a suitable platform to other research networks. The development of such an infrastructure serves all parties - mostly the funding agencies. This objective could be achieved by the integration of several portals of different research networks and the interfacing between these portals to maximize the usability and minimize the cost.