Plasminogen activator inhibitor-1 and restenosis

Curr Drug Targets. 2007 Sep;8(9):1003-6. doi: 10.2174/138945007781662355.

Abstract

Despite the introduction of drug-eluting stents restenosis remains an important clinical problem. In this review we examine the role of plasminogen activator inhibitor-1 (PAI-1) in controlling restenosis after balloon angioplasty and stent implantation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Angioplasty, Balloon, Coronary*
  • Animals
  • Coronary Restenosis / blood*
  • Coronary Restenosis / etiology
  • Coronary Restenosis / prevention & control
  • Humans
  • Hyperplasia / etiology
  • Hyperplasia / metabolism
  • Plasminogen Activator Inhibitor 1 / metabolism*
  • Tunica Intima / pathology

Substances

  • Plasminogen Activator Inhibitor 1