Abstract
In a previous work our group showed that some synthetic stigmastanes may play a role in immune-mediated inflammation. In this paper we report the syntheses of a series of new steroidal compounds derived from dehydroepiandrosterone and stigmasterol, and the evaluation of their in vitro inhibitory activity of the TNF-alpha production by macrophages. A preliminary qualitative structure-activity relationship was established.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Androstanes / chemical synthesis*
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Androstanes / chemistry
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Androstanes / pharmacology*
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Animals
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Cell Line
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Cholestanes / chemical synthesis*
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Cholestanes / chemistry
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Cholestanes / pharmacology*
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Dehydroepiandrosterone / chemistry
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Drug Evaluation, Preclinical
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Immunologic Factors / chemical synthesis
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Immunologic Factors / chemistry
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Immunologic Factors / pharmacology
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Mice
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Molecular Structure
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Stigmasterol / chemistry
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Structure-Activity Relationship
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Substances
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Androstanes
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Cholestanes
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Immunologic Factors
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Tumor Necrosis Factor-alpha
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Dehydroepiandrosterone
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Stigmasterol