Abstract
The ansacarbamitocins are a new family of maytansinoids that are unusually substituted with a glucose subunit and two carbamate functional groups and exhibit modest activity against some agricultural fungal disease organisms. Ansacarbamitocins A-F ( 1- 6) all consist of the same macrocyclic core as the ansamitocins, with variation occurring on the glucose unit, while ansacarbamitocins A1 and B1 ( 7, 8) additionally lack the epoxide group on C-4 and C-5.
MeSH terms
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Actinomycetales / chemistry*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / classification
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Ascomycota / drug effects
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Maytansine / analogs & derivatives*
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Maytansine / chemistry
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Maytansine / classification
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Maytansine / isolation & purification
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Maytansine / pharmacology
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Molecular Structure
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Maytansine
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ansamitocins