Supernumerary ring chromosomes accompanied with near-tetraploidy following chemotherapy and cranial radiation in a girl with a relapsed acute lymphoblastic leukemia

Cancer Genet Cytogenet. 2007 Oct 1;178(1):82-4. doi: 10.1016/j.cancergencyto.2007.07.001.

Abstract

Supernumerary ring chromosomes of different sizes and near-tetraploidy were presented in the bone marrow cells of 12-year-old girl with relapsed acute lymphoblastic leukemia who had been treated previously with chemotherapy and cranial radiation. Despite significant chromosomal abnormalities, complete hematologic and cytogenetic remissions were achieved.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Brain / radiation effects
  • Child
  • Chromosome Aberrations
  • Female
  • Humans
  • Karyotyping
  • Ploidies*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy
  • Radiotherapy / adverse effects
  • Remission Induction
  • Ring Chromosomes*

Substances

  • Antineoplastic Agents