Abstract
Supernumerary ring chromosomes of different sizes and near-tetraploidy were presented in the bone marrow cells of 12-year-old girl with relapsed acute lymphoblastic leukemia who had been treated previously with chemotherapy and cranial radiation. Despite significant chromosomal abnormalities, complete hematologic and cytogenetic remissions were achieved.
MeSH terms
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Antineoplastic Agents / therapeutic use*
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Brain / radiation effects
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Child
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Chromosome Aberrations
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Female
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Humans
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Karyotyping
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Ploidies*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy
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Radiotherapy / adverse effects
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Remission Induction
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Ring Chromosomes*