Unlocking the proteasome door

Mol Cell. 2007 Sep 21;27(6):865-7. doi: 10.1016/j.molcel.2007.09.001.

Abstract

How proteasomal ATPases stimulate the gate opening of 20S proteasomes is a longstanding question. In the September 7 issue of Molecular Cell, Smith et al. (2007) describe the conserved "HbYX" motif as the key to proteasome gate opening.

Publication types

  • Comment

MeSH terms

  • Adenosine Triphosphatases / metabolism
  • Adenosine Triphosphate / metabolism
  • Amino Acid Motifs
  • Animals
  • Archaeal Proteins / chemistry
  • Archaeal Proteins / metabolism
  • Proteasome Endopeptidase Complex / chemistry
  • Proteasome Endopeptidase Complex / metabolism*
  • Protein Conformation
  • Saccharomyces cerevisiae / metabolism
  • Substrate Specificity

Substances

  • Archaeal Proteins
  • Adenosine Triphosphate
  • Proteasome Endopeptidase Complex
  • Adenosine Triphosphatases