IA, database of known ligands of aminoacyl-tRNA synthetases

J Comput Aided Mol Des. 2007 Sep;21(9):523-5. doi: 10.1007/s10822-007-9135-x. Epub 2007 Sep 20.

Abstract

The IA database contains 240 structures of known inhibitors of aminoacyl-tRNA synthetases. Structures can be downloaded in different file formats (mol, sdf, smile, png). The search engine offers possibility of searching for the ligands with a given functional group. Additionally, one can search for ligands that act on selected synthetases and from particular references. The data include information which synthetase a given ligand inhibits together with the inhibition constant (IC50) if known.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acyl-tRNA Synthetases / chemistry*
  • Amino Acyl-tRNA Synthetases / genetics
  • Amino Acyl-tRNA Synthetases / metabolism
  • Binding Sites
  • Databases, Factual*
  • Kinetics
  • RNA, Transfer*
  • Structure-Activity Relationship

Substances

  • RNA, Transfer
  • Amino Acyl-tRNA Synthetases