Serious haematological toxicity of cyclophosphamide in relation to CYP2B6, GSTA1 and GSTP1 polymorphisms

Br J Clin Pharmacol. 2008 Feb;65(2):279-80. doi: 10.1111/j.1365-2125.2007.03020.x. Epub 2007 Sep 13.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Cyclophosphamide / adverse effects*
  • Cytochrome P-450 CYP2B6
  • Female
  • Glutathione S-Transferase pi / genetics*
  • Glutathione Transferase / genetics*
  • Hematologic Diseases / chemically induced*
  • Hematologic Diseases / diagnosis
  • Hematologic Diseases / enzymology
  • Humans
  • Oxidoreductases, N-Demethylating / genetics*
  • Polymorphism, Genetic / genetics

Substances

  • Cyclophosphamide
  • Aryl Hydrocarbon Hydroxylases
  • CYP2B6 protein, human
  • Cytochrome P-450 CYP2B6
  • Oxidoreductases, N-Demethylating
  • GSTA1 protein, human
  • GSTP1 protein, human
  • Glutathione S-Transferase pi
  • Glutathione Transferase