Abstract
An 11-y-old girl diagnosed with HIV-1, presented with prolonged pyrexia and a non-reactive tuberculin skin test. An INF-gamma assay (ELISpot) was positive and led to administration of tuberculosis treatment. Positive cultures for Mycobacterium tuberculosis followed 6 weeks later. INF-gamma assays should be considered as first line investigations in HIV-1 infected subjects when TB is a diagnostic possibility.
MeSH terms
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AIDS-Related Opportunistic Infections / diagnosis*
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AIDS-Related Opportunistic Infections / drug therapy
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AIDS-Related Opportunistic Infections / microbiology
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Anti-HIV Agents / therapeutic use
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Antitubercular Agents / therapeutic use
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CD4 Lymphocyte Count
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Child
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Female
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HIV Infections / complications*
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HIV Infections / drug therapy
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HIV Infections / immunology
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HIV-1
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Humans
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Interferon-gamma / analysis*
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Mycobacterium tuberculosis / isolation & purification
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Time Factors
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Tuberculosis, Pulmonary / diagnosis*
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Tuberculosis, Pulmonary / drug therapy
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Tuberculosis, Pulmonary / microbiology
Substances
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Anti-HIV Agents
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Antitubercular Agents
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Interferon-gamma