Early diagnosis of tuberculosis using an INF-gamma assay in a child with HIV-1 infection and a very low CD4 count

Scand J Infect Dis. 2007;39(10):919-21. doi: 10.1080/00365540701481537.

Abstract

An 11-y-old girl diagnosed with HIV-1, presented with prolonged pyrexia and a non-reactive tuberculin skin test. An INF-gamma assay (ELISpot) was positive and led to administration of tuberculosis treatment. Positive cultures for Mycobacterium tuberculosis followed 6 weeks later. INF-gamma assays should be considered as first line investigations in HIV-1 infected subjects when TB is a diagnostic possibility.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / diagnosis*
  • AIDS-Related Opportunistic Infections / drug therapy
  • AIDS-Related Opportunistic Infections / microbiology
  • Anti-HIV Agents / therapeutic use
  • Antitubercular Agents / therapeutic use
  • CD4 Lymphocyte Count
  • Child
  • Female
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • HIV Infections / immunology
  • HIV-1
  • Humans
  • Interferon-gamma / analysis*
  • Mycobacterium tuberculosis / isolation & purification
  • Time Factors
  • Tuberculosis, Pulmonary / diagnosis*
  • Tuberculosis, Pulmonary / drug therapy
  • Tuberculosis, Pulmonary / microbiology

Substances

  • Anti-HIV Agents
  • Antitubercular Agents
  • Interferon-gamma