Abstract
A series of N- and C-alkylated amino alcohols and of their protected galactopyranosyl derivatives was synthesized and evaluated for antitubercular activity. Five of these compounds displayed good activity, with a MIC below 12.5mug/mL. The presence of the carbohydrate slightly affected the antibacterial activity.
MeSH terms
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Alkylation
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Amino Alcohols / chemical synthesis*
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Amino Alcohols / chemistry
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Amino Alcohols / pharmacology*
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Antitubercular Agents / chemical synthesis*
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Antitubercular Agents / chemistry
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Antitubercular Agents / pharmacology*
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Cell Proliferation
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Cells, Cultured
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Glycosylation
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Microbial Sensitivity Tests
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Molecular Structure
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Mycobacterium tuberculosis / drug effects*
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Structure-Activity Relationship
Substances
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Amino Alcohols
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Antitubercular Agents