Emergence of the quinolone resistance-mediating gene aac(6')-Ib-cr in extended-spectrum-beta-lactamase-producing Klebsiella isolates collected in Slovenia between 2000 and 2005

Antimicrob Agents Chemother. 2007 Nov;51(11):4171-3. doi: 10.1128/AAC.01480-06. Epub 2007 Sep 10.

Abstract

Seventy-four nonrepetitive uropathogenic fluoroquinolone-resistant or -intermediate extended-spectrum-beta-lactamase-producing Klebsiella isolates from Slovenia were screened for the presence of plasmid-mediated quinolone resistance genes. None of the known qnr genes were detected. The aac(6')-Ib-cr allele was detected on plasmids from 25 transconjugants for which the ciprofloxacin MIC was higher than for the recipient Escherichia coli strain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ciprofloxacin / pharmacology
  • DNA, Bacterial / analysis
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial / genetics*
  • Enterobacteriaceae Infections / microbiology
  • Enterobacteriaceae Infections / urine
  • Humans
  • Klebsiella / drug effects*
  • Klebsiella / enzymology
  • Klebsiella / growth & development
  • Microbial Sensitivity Tests
  • Plasmids / genetics
  • Quinolones / pharmacology*
  • Slovenia
  • beta-Lactamases / metabolism*

Substances

  • DNA, Bacterial
  • Quinolones
  • Ciprofloxacin
  • beta-Lactamases