Abstract
Seventy-four nonrepetitive uropathogenic fluoroquinolone-resistant or -intermediate extended-spectrum-beta-lactamase-producing Klebsiella isolates from Slovenia were screened for the presence of plasmid-mediated quinolone resistance genes. None of the known qnr genes were detected. The aac(6')-Ib-cr allele was detected on plasmids from 25 transconjugants for which the ciprofloxacin MIC was higher than for the recipient Escherichia coli strain.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ciprofloxacin / pharmacology
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DNA, Bacterial / analysis
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial / genetics*
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Enterobacteriaceae Infections / microbiology
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Enterobacteriaceae Infections / urine
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Humans
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Klebsiella / drug effects*
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Klebsiella / enzymology
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Klebsiella / growth & development
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Microbial Sensitivity Tests
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Plasmids / genetics
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Quinolones / pharmacology*
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Slovenia
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beta-Lactamases / metabolism*
Substances
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DNA, Bacterial
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Quinolones
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Ciprofloxacin
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beta-Lactamases