Supramolecular synthon polymorphism in 2 : 1 co-crystal of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine

Chem Commun (Camb). 2007 Jun 21:(23):2375-7. doi: 10.1039/b700082k.

Abstract

Co-crystals of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine (2 : 1) exhibit the first supramolecular synthon polymorphism in a co-crystal; metastable anti-hierarchic polymorph I converts to stable hierarchic form II.

MeSH terms

  • Crystallization
  • Hydrogen Bonding
  • Models, Molecular
  • Parabens / chemistry*
  • Pyrazines / chemistry*

Substances

  • Parabens
  • Pyrazines
  • 4-hydroxybenzoic acid
  • tetramethylpyrazine