Juvenile hormone activity of ethyl 4-(2-aryloxyhexyloxy)benzoates with precocious metamorphosis-inducing activity

Biosci Biotechnol Biochem. 2007 Sep;71(9):2333-4. doi: 10.1271/bbb.70265. Epub 2007 Sep 7.

Abstract

Ethyl 4-[2-(6-methyl-3-pyridyloxy)hexyloxy]benzoate (1) and ethyl 4-(2-phenoxyhexyloxy)benzoate (2), which induce precocious metamorphosis in larvae of Bombyx mori, a clear sign of juvenile hormone (JH) deficiency, showed JH activity when topically applied to allatectomized 4th instar larvae of B. mori. Compounds 1 and 2 induced precocious metamorphosis with doses at which they were effective as JH agonists.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzoic Acid / chemistry*
  • Benzoic Acid / pharmacology*
  • Bombyx / drug effects*
  • Bombyx / growth & development*
  • Juvenile Hormones / chemistry
  • Juvenile Hormones / pharmacology*
  • Larva / drug effects
  • Larva / growth & development
  • Metamorphosis, Biological / drug effects*
  • Molecular Structure

Substances

  • Juvenile Hormones
  • Benzoic Acid