Serum angiogenin (ANG) levels were measured with ELISA in 30 cerebral infarction patients at different time points (within 48 h and on days 3, 7 and 14 after onset of cerebral infarction) and in 20 control subjects. Serum ANG levels in patients were 415.1 +/- 76.8, 410.6 +/- 82.1, 443.6 +/- 91.1 and 395.3 +/- 83.9 ng/ml within 48 h and on days 3, 7 and 14 after cerebral infarction, respectively. Serum ANG level in control group was 334.9 +/- 93.9 ng/ml. Serum ANG levels were significantly higher in patients with cerebral infarction within 48 h and on days 3 and 7 than in the control group (p < 0.05). Serum ANG level decreased on day 14. Serum ANG levels were significantly higher in patients with large infarction than in those with moderate and small infarction at each time point (p < 0.05). Our observations that serum ANG levels increase significantly in patients with cerebral infarction and the increase in ANG levels correlates with the infarct size suggest that ANG might be involved in the pathophysiologic process of ischemic brain damage.
(c) 2007 S. Karger AG, Basel.