Abstract
Experimental diabetes induced by streptozotocin (200 mg/kg, ip) markedly decreased the antinociceptive effect of morphine and significantly increased the urinary nitrite concentration. Administration of FR-167653 (a selective p38MAPKinase inhibitor) in a dose of 4 mg/kg improved the antinociceptive effect of morphine and attenuated the increase in urinary nitrite concentration in diabetic mice. It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity.
MeSH terms
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Analgesics / pharmacology*
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Analgesics, Opioid / pharmacology*
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Animals
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Blood Glucose / metabolism
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Cyclooxygenase Inhibitors / chemistry
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Cyclooxygenase Inhibitors / pharmacology*
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Drug Design
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Female
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Male
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Mice
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Models, Statistical
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Morphine / pharmacology*
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Nitrites / chemistry
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Nitrites / metabolism
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Nitrites / urine
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Pyrazoles / pharmacology*
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Pyridines / pharmacology*
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p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors
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p38 Mitogen-Activated Protein Kinases / metabolism*
Substances
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Analgesics
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Analgesics, Opioid
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Blood Glucose
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Cyclooxygenase Inhibitors
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FR 167653
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Nitrites
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Pyrazoles
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Pyridines
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Morphine
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p38 Mitogen-Activated Protein Kinases