Nerve growth factor as an angiogenic factor

Beatrice Nico; Domenica Mangieri; Vincenzo Benagiano; Enrico Crivellato; Domenico Ribatti

doi:10.1016/j.mvr.2007.07.004

Nerve growth factor as an angiogenic factor

Microvasc Res. 2008 Mar;75(2):135-41. doi: 10.1016/j.mvr.2007.07.004. Epub 2007 Jul 21.

Authors

Beatrice Nico¹, Domenica Mangieri, Vincenzo Benagiano, Enrico Crivellato, Domenico Ribatti

Affiliation

¹ Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico, 70124 Bari, Italy.

PMID: 17764704
DOI: 10.1016/j.mvr.2007.07.004

Abstract

Nerve growth factor (NGF), a neurotrophin that plays a crucial role in promoting neurotrophic and neurotropic effects in sympathetic neurons, has recently been identified as a novel angiogenic molecule, which exerts a variety of effects in the cardiovascular system and on endothelial cells. In fact, NGF may contribute to maintenance, survival, and function of endothelial cells by autocrine and/or paracrine mechanisms. This review summarizes the involvement of NGF in the regulation of angiogenesis in both normal and pathological conditions.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Angiogenic Proteins / metabolism*
Animals
Cell Proliferation
Endothelial Cells / metabolism*
Humans
Ischemia / metabolism
Ischemia / physiopathology
Neoplasms / blood supply
Neoplasms / metabolism
Neoplasms / pathology
Neovascularization, Pathologic / metabolism
Neovascularization, Pathologic / physiopathology
Neovascularization, Physiologic*
Nerve Growth Factor / metabolism*
Signal Transduction
Vascular Endothelial Growth Factor A / metabolism
Wound Healing

Substances

Angiogenic Proteins
Vascular Endothelial Growth Factor A
Nerve Growth Factor