Linkage of bipolar affective disorders to markers on chromosome 11p is excluded in a second lateral extension of Amish pedigree 110

D L Pauls; D S Gerhard; L G Lacy; A M Hostetter; C R Allen; S D Bland; M C LaBuda; J A Egeland

doi:10.1016/0888-7543(91)90081-o

Linkage of bipolar affective disorders to markers on chromosome 11p is excluded in a second lateral extension of Amish pedigree 110

Genomics. 1991 Nov;11(3):730-6. doi: 10.1016/0888-7543(91)90081-o.

Authors

D L Pauls¹, D S Gerhard, L G Lacy, A M Hostetter, C R Allen, S D Bland, M C LaBuda, J A Egeland

Affiliation

¹ Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.

PMID: 1774072
DOI: 10.1016/0888-7543(91)90081-o

Abstract

Linkage between markers on chromosome 11p and bipolar affective disorders can be excluded in a second large lateral extension of the original Amish Pedigree 110. These results, together with previous negative linkage findings, suggest that there is not one single gene on 11p conferring susceptibility for bipolar affective disorders among the Old Order Amish.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adult
Aged
Aged, 80 and over
Bipolar Disorder / ethnology
Bipolar Disorder / genetics*
Chromosomes, Human, Pair 11*
DNA Probes / genetics
Female
Genetic Linkage / genetics*
Genetic Markers / genetics
Humans
Male
Middle Aged
Pedigree
Recombination, Genetic / genetics
Restriction Mapping

Substances

DNA Probes
Genetic Markers

Grants and funding

etc