Objective: It has been difficult to determine the sources of U.S. dietary iodine. This study was designed to validate a self-administered questionnaire about dietary iodine sources.
Design: We constructed a questionnaire to assess iodine intake in 46 healthy Boston-area adult volunteers. Questionnaire information was correlated with subjects' 24-hour food diaries. Spot morning urine cotinine (a metabolite of nicotine from cigarette smoking) and iodine concentrations were measured.
Main outcomes: 91% of 46 subjects were women [mean (+/- SD) age of 38 (+/- 10) years]. Information from 24-hour food diaries correlated well with questionnaire data. The median urinary iodine concentration (UIC) was 140 microg/L (range: 18-845 microg/L). There were significant positive associations between intake of yogurt (n = 9, p = 0.01) and saltwater fish (n = 6, p = 0.0003), and an inverse correlation between bagels (n = 5, p = 0.0006) and UIC. We found no associations between self-reported milk, iodized salt, tobacco use, or urinary cotinine and UIC.
Conclusion: The questionnaire may not have been sufficiently comprehensive. Given the importance of adequate dietary iodine intake, particularly among women of childbearing age, further studies are warranted to determine important sources of dietary iodine in the United States.